Article
FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile.
Thrombosis and haemostasis - 1 Jan 2002
Margaglione Maurizio, Bossone Anna, Coalizzo Donatella, D'Andrea Giovanna, Brancaccio Vincenzo, Ciampa Antonio, Grandone Elvira, Di Minno Giovanni
Abstract excerpt
A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in...
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