Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.

Thrombosis and haemostasis - 1 Apr 2000

de Visser M C, Guasch J F, Kamphuisen P W, Vos H L, Rosendaal F R, Bertina R M

Abstract excerpt

We studied the HR2 haplotype of the factor V gene in a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched healthy controls (Leiden Thrombophilia Study, LETS). We investigated both the original His1299Arg (A4070G) polymorphism and the Met385Thr (T1328C) polymorphism. This latter polymorphism, located in exon 8 (heavy chain), is always...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activated Protein C Resistance
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor V

Share to Factor VIII

Share to Netherlands

Share to Point Mutation

Share to Thrombophilia

Share to Venous Thrombosis

Source

Identifiers

PMID: 10780320

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.PMID 10780320Read ↗

Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis.Semantic proximity Read ↗

FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile.Semantic proximity Read ↗

Factor-V HR2 haplotype and thromboembolic disease.Semantic proximity Read ↗

Factor V HR2 haplotype: a risk factor for venous thromboembolism in individuals with absence of Factor V Leiden.Semantic proximity Read ↗

Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism.Semantic proximity Read ↗

A case control study of deep venous thrombosis in relation to factor V G1691A (Leiden) and A4070G (HR2 Haplotype) polymorphisms.Semantic proximity Read ↗

A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype.Semantic proximity Read ↗

Is homozygosity for the HR2 haplotype a risk factor for venous thromboembolism?Semantic proximity Read ↗

Prevalence of factor V R2 (H1299R) polymorphism in the Lebanese population.Semantic proximity Read ↗

A prospective study of venous thromboembolism in relation to factor V Leiden and related factors.Semantic proximity Read ↗

Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden).Semantic proximity Read ↗

The factor V R2 allele: risk of venous thromboembolism, factor V levels and resistance to activated protein C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.