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Article

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

7 Feb 2007

Abstract excerpt

BACKGROUND: Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet. RESULTS: We employed a microarray analysis covering 12,488 genes and ESTs using...

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PMID: 17286852
DOI: 10.1186/1471-2164-8-41

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