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Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis.

Human mutation - 1 May 2007

Hu Zhibin, Wang Haifeng, Shao Minhua, Jin Guangfu, Sun Weiwei, Wang Yi, Liu Hongliang, Wang Ying, Ma Hongxia, Qian Ji, Jin Li, Wei Qingyi, Lu Daru, Huang Wei, Shen Hongbing

Abstract excerpt

O6-alkylguanine-DNA alkyltransferase (MGMT) is a universal DNA repair protein involved in the DNA direct reversal repair pathway that copes with alkylating carcinogens. Reduced MGMT expression as well as enzyme activity may result in an increased susceptibility to cancers. To elucidate the role of sequence variation in MGMT in the etiology of lung cancer, we conducted a comprehensive association study focusing on...

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Identifiers

PMID: 17285603
DOI: 10.1002/humu.20462

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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