Article
Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.
Carcinogenesis - 1 Sept 2013
Deng Qifei, Guo Huan, Dai Juncheng, Yang Lei, Wu Chen, Wang Qing, Hu Zhibin, Yang Ming, Liu Li, Yu Dianke, Hu Die, Hong Xiaohua, Qiu Fuman, Yang Handong, Wang Tian, Tan Wen, Chu Minjie, Feng Jing, Teng Kai, Gong Jianhang, Sun Chongqi, Hu Xiaoyan, Zhang Kai, Lu Jiachun, Lin Dongxin, Shen Hongbing, Wu Tangchun
Abstract excerpt
Cell cycle regulation, apoptosis, oxidative stress and inflammation response play critical roles in the development of smoking-induced lung cancer. However, it is still not well known whether their genetic variants are associated with lung cancer susceptibility. In this study, we performed imputation-based association analyses to investigate the influence of common genetic variants in these pathways and their...
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