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Article

Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

Cancer research - 1 Aug 2015

Leng Shuguang, Wu Guodong, Collins Leonard B, Thomas Cynthia L, Tellez Carmen S, Jauregui Andrew R, Picchi Maria A, Zhang Xiequn, Juri Daniel E, Desai Dhimant, Amin Shantu G, Crowell Richard E, Stidley Christine A, Liu Yushi, Swenberg James A, Lin Yong, Wathelet Marc G, Gilliland Frank D, Belinsky Steven A

Abstract excerpt

O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that protects cells from carcinogenic effects of alkylating agents; however, MGMT is silenced by promoter hypermethylation during carcinogenesis. A single-nucleotide polymorphism (SNP) in an enhancer in the MGMT promoter was previously identified to be highly significantly associated with risk for MGMT methylation in lung cancer and sputum...

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Share to Chromosomes, Human, Pair 15
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Epithelial Cells

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Share to Methylnitrosourea

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Source

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Identifiers

PMID: 26183928
DOI: 10.1158/0008-5472.CAN-15-0243
PMCID: PMC4526392

Genes

MGMT
UBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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