Article
A model for triplet mutation formation based on error-prone translesional DNA synthesis opposite UV photolesions.
DNA repair - 1 May 2007
Ikehata Hironobu, Ono Tetsuya, Tanaka Kiyoji, Todo Takeshi
Abstract excerpt
A triplet mutation is defined as multiple base substitutions or frameshifts within a three-nucleotide sequence which includes a dipyrimidine sequence. Triplet mutations have recently been identified as a new type of UV-specific mutation, although the mechanism of their formation is unknown. A total of 163 triplet mutations were identified through an extensive search of previously published data on UV-induced...
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