Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.

doi:10.1128/JVI.66.1.567-572.1992

Back to search

Article

Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.

Journal of virology - 1 Jan 1992

Kräusslich H G

Abstract excerpt

The active form of the retroviral proteinase (PR) is a homodimer of monomeric subunits expressed as integral parts of the viral gag-pol precursor polyproteins, and dimerization of polyproteins is presumed to be important for regulation of PR activity. Expression of a single-chain dimer of the hum...

Topics

Blotting, Western
Cell Line
Fluorescent Antibody Technique
HIV Protease
HIV Protease Inhibitors
HIV-1
Phenotype
Protein Processing, Post-Translational
Saquinavir
Transfection
Viral Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.