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Article

Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.

Journal of virology - 1 Sept 2005

Abram Michael E, Parniak Michael A

Abstract excerpt

Each of the human immunodeficiency virus type 1 (HIV-1) pol-encoded enzymes, protease (PR), reverse transcriptase (RT), and integrase (IN), is active only as a dimer (or higher-order oligomer in the case of IN), but only RT comprises subunits of different masses. RT is a heterodimer of 66-kDa and 51-kDa subunits. The latter is formed by HIV PR-catalyzed cleavage of p66 during virion maturation, resulting in the...

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Identifiers

PMID: 16140771
DOI: 10.1128/JVI.79.18.11952-11961.2005
PMCID: PMC1212597

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