Article
[X-chromosomal inactivation skewing in blood cells is associated with early development of lung].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Sept 2006
Li Gang, Su Qin, Liu Gui-qiu, Gong Li, Zhang Wei, Zhu Shao-jun, Zhang He-long, Feng Ying-ming, Zhang Yu-hai
Abstract excerpt
OBJECTIVE: To observe the relationship between skewed X-chromosomal inactivation (SXCI) and development of lung cancer in females. METHODS: DNA was isolated from peripheral blood cells from patients with primary lung cancer (n = 148) and control subjects (n =289). Exon 1 of androgen receptor ( AR) gene was amplified, with its products from different alleles resolved on denaturing polyacrylamide gels and...
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