Article
Skewed X chromosome inactivation of blood cells is associated with early development of lung cancer in females.
Oncology reports - 1 Oct 2006
Li Gang, Su Qin, Liu Gui-Qiu, Gong Li, Zhang Wei, Zhu Shao-Jun, Zhang He-Long, Feng Ying-Ming
Abstract excerpt
The skewed X chromosome inactivation (SXCI) was found mainly in adult females. It has been linked to development of ovarian and breast cancers. The present study aimed to describe the relationship between SXCI and development of lung cancer in females. DNA was isolated from blood cells from patients with primary lung cancer (n=148) and reference subjects (n=289). The androgen receptor (AR) gene exon 1 was...
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