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Article

The vitamin D receptor gene <i>Fok</i>I polymorphism: Functional impact on the immune system

1 Feb 2007

Abstract excerpt

1Alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important effects on the growth and function of multiple cell types. These pleiotropic effects of 1,25(OH)2D3 are mediated through binding to the vitamin D receptor (VDR). Several polymorphisms of the human VDR gene have been identified, with the FokI polymorphism resulting in VDR proteins with different structures, a long f-VDR or a shorter F-VDR. The aim of this...

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PMID: 17274004
DOI: 10.1002/eji.200636043

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