Article
The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 1998
Gross C, Krishnan A V, Malloy P J, Eccleshall T R, Zhao X Y, Feldman D
Abstract excerpt
The vitamin D receptor (VDR) gene contains a start codon polymorphism (SCP) which is three codons upstream of a second start site (ATG). The SCP genotype can be determined with the restriction enzyme FokI, where "f" indicates the presence of the restriction site and the first ATG, while "F" indic...
Topics
- Analysis of Variance
- Animals
- Bone Density
- COS Cells
- Cells, Cultured
- Codon, Initiator
- DNA
- Fibroblasts
- Genes, Reporter
- Genotype
- Humans
- Immunoblotting
- Polymorphism, Genetic
- Receptors, Calcitriol
- Transcriptional Activation