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Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk

15 Aug 2004

Abstract excerpt

PURPOSE: The steroid hormone 1,25-dihydroxyvitamin D3 is thought to protect against breast cancer. The actions of 1,25-dihydroxyvitamin D3 are mediated via the vitamin D receptor (VDR), and a number of polymorphisms in the VDR gene have been identified. These result in distinct genotypes, some of which may alter susceptibility to breast cancer. We have investigated whether specific VDR gene polymorphisms are...

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PMID: 15328186
DOI: 10.1158/1078-0432.ccr-04-0206

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