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Article

Histone chaperone specificity in Rtt109 activation.

Nature structural & molecular biology - 1 Sept 2008

Park Young-Jun, Sudhoff Keely B, Andrews Andrew J, Stargell Laurie A, Luger Karolin

Abstract excerpt

Rtt109 is a histone acetyltransferase that requires a histone chaperone for the acetylation of histone 3 at lysine 56 (H3K56). Rtt109 forms a complex with the chaperone Vps75 in vivo and is implicated in DNA replication and repair. Here we show that both Rtt109 and Vps75 bind histones with high affinity, but only the complex is efficient for catalysis. The C-terminal acidic domain of Vps75 contributes to...

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Identifiers

PMID: 19172749
DOI: 10.1038/nsmb.1480
PMCID: PMC2680711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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