Article
Histone acetyltransferase 1 is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cells.
Biochemical and biophysical research communications - 14 Jul 2006
Barman Hirak Kumar, Takami Yasunari, Ono Tatsuya, Nishijima Hitoshi, Sanematsu Fumiyuki, Shibahara Kei-ichi, Nakayama Tatsuo
Abstract excerpt
Histone acetyltransferase 1 (HAT1) is implicated for diacetylation of Lys-5 and Lys-12 of newly synthesized histone H4, the biological significance of which remains unclear. To investigate the in vivo role of HAT1, we generated HAT1-deficient DT40 clone (HAT1(-/-)). HAT1(-/-) cells exhibited greatly reduced diacetylation levels of Lys-5 and Lys-12, and acetylation level of Lys-5 of cytosolic and chromatin...
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