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Article

Integrin beta3 Leu33Pro homozygosity and risk of cancer.

Journal of the National Cancer Institute - 6 Aug 2003

Bojesen Stig E, Tybjaerg-Hansen Anne, Nordestgaard Børge G

Abstract excerpt

BACKGROUND: Increased tumor cell expression of integrins containing the beta3 subunit is associated with increased progression to invasive tumors, whereas inhibition of beta3 integrin expression and/or function may reduce tumor growth and metastasis. The Leu33Pro polymorphism of the beta3 subunit modulates the function of alpha(IIb)beta3 integrin. We examined whether this polymorphism influences cancer risk....

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Identifiers

PMID: 12902444
DOI: 10.1093/jnci/djg005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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