Article
Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study.
Bone - 1 May 2008
Langdahl Bente L, Uitterlinden André G, Ralston Stuart H, Trikalinos Thomas A, Balcells Susanne, Brandi Maria Luisa, Scollen Serena, Lips Paul, Lorenc Roman, Obermayer-Pietsch Barbara, Reid David M, Armas Jácome Bruges, Arp Pascal P, Bassiti Amelia, Bustamante Mariona, Husted Lise Bjerre, Carey Alison H, Pérez Cano Ramon, Dobnig Harald, Dunning Alison M, Fahrleitner-Pammer Astrid, Falchetti Alberto, Karczmarewicz Elzbieta, Kruk Marcin, van Leeuwen Johannes P T M, Masi Laura, van Meurs Joyce B J, Mangion Jon, McGuigan Fiona E A, Mellibovsky Leonardo, Mosekilde Leif, Nogués Xavier, Pols Huibert A P, Reeve Jonathan, Renner Wilfried, Rivadeneira Fernando, van Schoor Natasja M, Ioannidis John P A
Abstract excerpt
INTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results. METHODS: We investigated associations between TGFB1 polymorphisms and BMD and fracture in...
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