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Article

Axons break in animals lacking beta-spectrin.

The Journal of cell biology - 29 Jan 2007

Hammarlund Marc, Jorgensen Erik M, Bastiani Michael J

Abstract excerpt

Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that beta-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in beta-spectrin mutants spontaneously break. Breakage is caused by acute strain generated by movement because breakage can be prevented by paralyzing the mutant animals....

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Identifiers

PMID: 17261846
DOI: 10.1083/jcb.200611117
PMCID: PMC2063953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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