Article
Distinct functions of alpha-Spectrin and beta-Spectrin during axonal pathfinding.
Development (Cambridge, England) - 1 Feb 2007
Hülsmeier Jörn, Pielage Jan, Rickert Christof, Technau Gerd M, Klämbt Christian, Stork Tobias
Abstract excerpt
Cell-shape changes during development require a precise coupling of the cytoskeleton with proteins situated in the plasma membrane. Important elements controlling the shape of cells are the Spectrin proteins that are expressed as a subcortical cytoskeletal meshwork linking specific membrane receptors with F-actin fibers. Here, we demonstrate that Drosophila karussell mutations affect beta-spectrin and lead to...
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