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The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

2 Sept 2022

Abstract excerpt

Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR antibodies are naturally occurring heavy-chain-only antibodies, that recognize antigens with their single domain variable regions (VNARs). In this study, we...

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PMID: 36177031
DOI: 10.3389/fimmu.2022.953917

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