Article
Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes.
Tissue antigens - 1 Feb 2007
Wiencke K, Karlsen T H, Boberg K M, Thorsby E, Schrumpf E, Lie B A, Spurkland A
Abstract excerpt
Primary sclerosing cholangitis (PSC) is associated with the human leukocyte antigen (HLA)-DRB1*0301-DQA1*0501-DQB1*0201 (DR3) and HLA-DRB1*1301-DQA1*0103-DQB1*0603 (DR6) haplotypes. Recently, the extended HLA class I region has been found to harbour genes that modulate or confer susceptibility independently of the HLA class II genes in several immune-mediated diseases. The aim of the present study was to evaluate...
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