Article
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease.
Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2014
Naess Sigrid, Björnsson Einar, Anmarkrud Jarl A, Al Mamari Said, Juran Brian D, Lazaridis Konstantinos N, Chapman Roger, Bergquist Annika, Melum Espen, Marsh Steven G E, Schrumpf Erik, Lie Benedicte A, Boberg Kirsten M, Karlsen Tom H, Hov Johannes R
Abstract excerpt
BACKGROUND & AIMS: Small duct primary sclerosing cholangitis (PSC) is phenotypically a mild version of large duct PSC, but it is unknown whether these phenotypes share aetiology. We aimed to characterize their relationship by investigating genetic associations in the human leucocyte antigen (HLA) complex, which represent the strongest genetic risk factors in large duct PSC. METHODS: Four classical HLA loci...
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