Article
HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations.
Tissue antigens - 1 May 1999
Spurkland A, Saarinen S, Boberg K M, Mitchell S, Broome U, Caballeria L, Ciusani E, Chapman R, Ercilla G, Fausa O, Knutsen I, Pares A, Rosina F, Olerup O, Thorsby E, Schrumpf E
Abstract excerpt
The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR=3.0, P<0.00001) and the...
Topics
- Adolescent
- Adult
- Aged
- Child
- Cholangitis, Sclerosing
- Europe
- Female
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- HLA-DRB3 Chains