Article
Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment.
Virology - 1 Mar 1992
Günther S, Meisel H, Reip A, Miska S, Krüger D H, Will H
Abstract excerpt
Hepatitis B virus (HBV) variants which cannot express e-antigen (HBeAg) are characteristic for many viremic anti-HBe positive chronic carriers who often have particularly severe and fluctuating hepatitis. Whether such variants are selected for and are less amenable to interferon treatment is under dispute. Therefore, by DNA amplification and direct sequencing we have investigated the emergence of HBV pre-C...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Carrier State
- Codon
- DNA, Viral
- Female
- Genetic Variation
- Genome, Viral
- Hepatitis B
- Hepatitis B Antibodies