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Article

Characteristics of nucleotide substitution in the hepatitis C virus genome: constraints on sequence change in coding regions at both ends of the genome.

Journal of molecular evolution - 1 Sept 1997

Smith D B, Simmonds P

Abstract excerpt

Comparison of complete genome sequences for different variants of hepatitis C virus (HCV) reveals several different constraints on sequence change. Synonymous changes are suppressed in coding regions at both 5' and 3' ends of the genome. No evidence was found for the existence of alternative read...

Topics

Base Sequence
Codon
Genes, Viral
Genetic Variation
Genome, Viral
Hepacivirus
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Phylogeny
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9302317
DOI: 10.1007/pl00006226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9302317-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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