Article
Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease.
Genetic testing - 1 Jan 2006
Funalot Benoît, Nichols William C, Pérez-Tur Jordi, Mercier Géraldine, Lucotte Gérard
Abstract excerpt
Several pathogenic mutations in the LRRK2 gene have been implicated in familial and sporadic cases of Parkinson's disease (PD). We screened 103 sporadic French PD patients for the presence of the LRRK2 R1441G and G2019S mutations. The R1441G mutation was absent in our PD sporadic cases, but the G2019S mutation was present in 2 of them (1.9%). Clinical features in our 2 patients were not different from classic PD....
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- Female
- France
- Genetic Testing
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Microsatellite Repeats