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Article

Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2007

Fairbrother Una L, Tankó László B, Walley Andrew J, Christiansen Claus, Froguel Philippe, Blakemore Alexandra I F

Abstract excerpt

UNLABELLED: Leptin is emerging as a key regulator of bone remodeling. In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture. Smoking exacerbates this LEPR-associated fracture risk. INTRODUCTION: Nonsynonymous single nucleotide polymorphisms (SNPs) in the human LEPR gene have been associated with adiposity in a...

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Source

Identifiers

PMID: 17243864
DOI: 10.1359/jbmr.070114

Genes

LEPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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