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Article

IL-1 family members as candidate genes modulating scrapie susceptibility in sheep: localization, partial characterization, and expression.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2007

Marcos-Carcavilla Ane, Calvo Jorge H, González Carmen, Moazami-Goudarzi Katayoun, Laurent Pascal, Bertaud Maud, Hayes Hélène, Beattie Anne E, Serrano Carmen, Lyahyai Jaber, Martín-Burriel Inmaculada, Alves Estefânia, Zaragoza Pilar, Badiola Juan J, Serrano Magdalena

Abstract excerpt

Scrapie (SC) is a transmissible spongiform encephalopathy (TSE) in sheep and goats. Susceptibility to this neurodegenerative disease is controlled mainly by point mutations at the PRNP locus. Other genes, apart from PRNP, have been reported to modulate resistance/susceptibility to SC. On the basis of several studies on Alzheimer's disease and different TSE models, and of requirement for correct homeostasis of...

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Identifiers

PMID: 17242860
DOI: 10.1007/s00335-006-0095-6

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IL-1 family members as candidate genes modulating scrapie susceptibility in sheep: localization, partial characterization, and expression.PMID 17242860Read ↗

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