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Article

Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2008

Marcos-Carcavilla Ane, Calvo Jorge H, González Carmen, Serrano Carmen, Moazami-Goudarzi Katayoun, Laurent Pascal, Bertaud Maud, Hayes Hélène, Beattie Anne E, Lyahyai Jaber, Martín-Burriel Inmaculada, Torres Juan María, Serrano Magdalena

Abstract excerpt

Scrapie is a prion disease affecting sheep and goats. Susceptibility to this neurodegenerative disease shows polygenic variance. The involvement of the laminin receptor (LRP/LR) in the metabolism and propagation of prions has previously been demonstrated. In the present work, the ovine laminin receptor gene (RPSA) was isolated, characterized, and mapped to ovine chromosome OAR19q13. Real-time RT-PCR revealed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18202837
DOI: 10.1007/s00335-007-9085-6

Genes

RPSA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and functional analysis of the ovine laminin receptor gene (RPSA): Possible involvement of the LRP/LR protein in scrapie response.PMID 18202837Read ↗

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