Article
Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage.
BMC veterinary research - 12 Sept 2018
Meling Siv, Skovgaard Kerstin, Bårdsen Kjetil, Helweg Heegaard Peter Mikael, Ulvund Martha J
Abstract excerpt
BACKGROUND: Incubation period, disease progression, pathology and clinical presentation of classical scrapie in sheep are highly dependent on PRNP genotype, time and route of inoculation and prion strain. Our experimental model with pre-colostrum inoculation of homozygous VRQ lambs has shown to be an effective model with extensive PrPSc dissemination in lymphatic tissue and a short incubation period with severe...
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