Article
Ovine PRNP untranslated region and promoter haplotype diversity.
The Journal of general virology - 1 May 2009
Saunders Ginny C, Cawthraw Saira, Mountjoy Susan J, Tout Anna C, Sayers Anthony R, Hope Jim, Windl Otto
Abstract excerpt
The diversity and possible contribution of non-coding regions of the prion protein (PrP) gene (PRNP) to transmissible spongiform encephalopathy susceptibility and PrP regulation are not fully known. This study defined ten ovine PRNP promoters and five untranslated region (UTR) haplotypes found in atypical and classical scrapie cases and healthy control sheep. A greater diversity of promoter and UTR haplotypes was...
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