Article
High-resolution diffracting crystals of intrinsically active p38alpha MAP kinase: a case study for low-throughput approaches.
Acta crystallographica. Section D, Biological crystallography - 1 Feb 2007
Diskin Ron, Engelberg David, Livnah Oded
Abstract excerpt
p38 MAP kinases are central signalling molecules that mediate cellular responses to numerous environmental conditions and signalling molecules. Their proper function is required for many processes, including stress response, apoptosis, differentiation, growth and even learning and memory. Abnormal activity of p38 MAP kinases is associated with the aetiology of many diseases, making understanding their activation...
Topics
- Crystallization
- Crystallography, X-Ray
- Mitogen-Activated Protein Kinase 14
- Mutation