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Article

Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.

Biochimica et biophysica acta - 14 Jan 2004

Patel Sangita B, Cameron Patricia M, Frantz-Wattley Betsy, O'Neill Edward, Becker Joseph W, Scapin Giovanna

Abstract excerpt

Mitogen-activated protein (MAP) kinase p38 alpha is activated in response to environmental stress and cytokines, and plays a significant role in inflammatory responses. For these reasons, it is an important target for the treatment of a wide range of inflammatory and autoimmune diseases. The crystals of p38 alpha that we obtained by published procedures were usually small, quite mosaic, and difficult to reproduce...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14726206
DOI: 10.1016/j.bbapap.2003.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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