Article
Dynamic characterization of HLA-B*44 Alleles: A comparative molecular dynamics simulation study.
Computational biology and chemistry - 1 Jun 2016
Ozbek Pemra
Abstract excerpt
Human Leukocyte Antigens (HLA) are highly polymorphic proteins that play a key role in the immune system. HLA molecule is present on the cell membrane of antigen-presenting cells of the immune system and presents short peptides, originating from the proteins of invading pathogens or self-proteins, to the T-cell Receptor (TCR) molecule of the T-cells. In this study, peptide-binding characteristics of HLA-B*44:02,...
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