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Article

Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-κB

22 Jan 2007

Abstract excerpt

Activation-induced cytidine deaminase (AID) is expressed in germinal centers of lymphoid organs during immunoglobulin diversification, in bone marrow B cells after infection with Abelson murine leukemia retrovirus (Ab-MLV), and in human B cells after infection by hepatitis C virus. To understand how viruses signal AID induction in the host we asked whether the AID response was abrogated in cells deficient in the...

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PMID: 17242162
DOI: 10.1084/jem.20061801

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