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Article

Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.

Biochimica et biophysica acta - 1 Mar 2007

Los Alrik P, de Widt John, Topham Matthew K, van Blitterswijk Wim J, Divecha Nullin

Abstract excerpt

We previously showed that the retinoblastoma protein (pRB), a key regulator of G1 to S-phase transition of the cell cycle, binds to and stimulates diacylglycerol kinase-zeta (DGKzeta) to phosphorylate the lipid second messenger diacylglycerol into phosphatidic acid. pRB binds to the MARCKS phosphorylation-site domain of DGKzeta that can be phosphorylated by protein kinase C (PKC). Here, we report that activation...

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Source

Identifiers

PMID: 17239975
DOI: 10.1016/j.bbamcr.2006.12.004

Genes

MARCKS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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