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Article

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

9 Feb 2008

Abstract excerpt

C1 domains mediate the recognition and subsequent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several other families of signal-transducing proteins such as the chimerins or RasGRP. MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase), a member of the dystrophia myotonica protein kinase family that functions downstream of Cdc42, contains a C1 domain with...

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PMID: 18263588
DOI: 10.1074/jbc.m707463200

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Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/βPMID 18263588Read ↗

Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.Semantic proximity Read ↗

Protein kinase C contains two phorbol ester binding domains.Semantic proximity Read ↗

Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.Semantic proximity Read ↗

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Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.Semantic proximity Read ↗

Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters.Semantic proximity Read ↗

Comparison of the roles of the C1a and C1b domains of protein kinase C alpha in ligand induced translocation in NIH 3T3 cells.Semantic proximity Read ↗

Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.Semantic proximity Read ↗

Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.Semantic proximity Read ↗

Dynamic re-distribution of protein kinase D (PKD) as revealed by a GFP-PKD fusion protein: dissociation from PKD activation.Semantic proximity Read ↗

Ligand regulation of bovine protein kinase C alpha response via either cysteine-rich repeat of conserved region C1.Semantic proximity Read ↗

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.Semantic proximity Read ↗

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