Article
Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.
Biochemical and biophysical research communications - 30 Nov 2001
Shindo M, Irie K, Ohigashi H, Kuriyama M, Saito N
Abstract excerpt
Diacylglycerol kinase (DGK) and protein kinase C (PKC) are two different enzyme families that interact with diacylglycerol. Both enzymes contain cysteine-rich C1 domains with a zinc finger-like structure. Most of the C1 domains of PKCs show strong phorbol-12,13-dibutyrate (PDBu) binding with nanomolar dissociation constants (K(d)'s). However, there has been no experimental evidence that phorbol esters bind to the...
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