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Article

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling.

Neurobiology of disease - 1 Apr 2007

George Ana, Leahy Hannah, Zhou Jianhua, Morin Peter J

Abstract excerpt

Endosomal acidification and transport are essential functions in signal transduction. Recent data suggest that Wnt signaling requires intact endosomal transport machinery but the effects of endosomal acidification on Wnt signal transduction have not been evaluated. Here we report that bafilomycin...

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Source

Identifiers

PMID: 17239604
DOI: 10.1016/j.nbd.2006.12.004

Genes

VPS35
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17239604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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