Article
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Nature cell biology - 1 Feb 2006
Hurtado-Lorenzo Andrés, Skinner Mhairi, El Annan Jaafar, Futai Masamitsu, Sun-Wada Ge-Hong, Bourgoin Sylvain, Casanova James, Wildeman Alan, Bechoua Shaliha, Ausiello Dennis A, Brown Dennis, Marshansky Vladimir
Abstract excerpt
The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification. The molecular mechanism that mediates this pH-sensitive recruitment and its role are unknown. Here, we demonstrate that Arf6 interacts with the c-subunit, and ARNO with the a2-isoform of V-ATPase. The a2-isoform is targeted to early endosomes, interacts with ARNO in...
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