Article
Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes.
The Journal of biological chemistry - 26 Mar 2004
Balbis Alejandro, Baquiran Gerardo, Dumas Victor, Posner Barry I
Abstract excerpt
Previous studies have shown that the endosomal apparatus plays an important role in insulin signaling. Inhibition of endosomal acidification leads to a decrease in insulin-insulin receptor kinase (IRK) dissociation and insulin degradation. Thus, vacuolar pH could function as a modulator of insulin signaling in endosomes. In the present study we show that in primary hepatocytes pretreated with bafilomycin, there...
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