Article
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.
Acta biochimica et biophysica Sinica - 1 Mar 2009
Tveten Kristian, Ranheim Trine, Berge Knut Erik, Leren Trond P, Kulseth Mari Ann
Abstract excerpt
The low-density lipoprotein receptor (LDLR) mediates cholesterol homeostasis through endocytosis of lipoprotein particles, particularly low-density lipoproteins (LDLs). Normally, the lipoprotein particles are released in the endosomes and the receptors recycle to the cell surface. Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the gene encoding the LDLR. These mutations...
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