Article

Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents

2022-12-19

Abstract excerpt

Voltage-gated sodium channels (Na v ) are key players in excitable tissues with the capability to generate and propagate action potentials. Mutations in the genes encoding Na v s can lead to severe inherited diseases, and some of these so-called channelopathies are showing temperature sensitive phenotypes, for example paramyotonia congenita, Brugada-syndrome, febrile seizure syndromes and inherited pain syndrome...

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Literature Corpus work: aef99977-94b0-5cb3-8924-e3fed0192dc4
DOI: 10.1101/2022.12.19.521077

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