Article
Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2007
Kelly Robert G, Papaioannou Virginia E
Abstract excerpt
Tbx1, the major gene underlying del22q11.2 or DiGeorge syndrome in humans, is required for normal development and septation of the cardiac outflow tract. The fibroblast growth factor 10 gene (Fgf10) and an Fgf10 enhancer trap transgene are expressed in outflow tract myocardial progenitor cells of the anterior heart field. To visualize outflow tract development in the absence of Tbx1, we have analyzed the...
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