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Article

The del22q11.2 Candidate Gene <i>Tbx1</i> Controls Regional Outflow Tract Identity and Coronary Artery Patterning

27 Jun 2008

Abstract excerpt

TBX1, encoding a T-box containing transcription factor, is the major candidate gene for del22q11.2 or DiGeorge syndrome, characterized by craniofacial and cardiovascular defects including tetralogy of Fallot and common arterial trunk. Mice lacking Tbx1 have severe defects in the development of pharyngeal derivatives including cardiac progenitor cells of the second heart field that contribute to the arterial pole...

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PMID: 18583714
DOI: 10.1161/circresaha.108.172189

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The del22q11.2 Candidate Gene <i>Tbx1</i> Controls Regional Outflow Tract Identity and Coronary Artery PatterningPMID 18583714Read ↗

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Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.Semantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo.Semantic proximity Read ↗

Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionSemantic proximity Read ↗

Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart DiseasesSemantic proximity Read ↗

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