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Article

Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.

Developmental biology - 15 Jul 2006

Vitelli Francesca, Zhang Zhen, Huynh Tuong, Sobotka Angela, Mupo Annalisa, Baldini Antonio

Abstract excerpt

Fgf8 and Tbx1 have been shown to interact in patterning the aortic arch, and both genes are required in formation and growth of the outflow tract of the heart. However, the nature of the interaction of the two genes is unclear. We have utilized a novel Tbx1(Fgf8) allele which drives Fgf8 expression in Tbx1-positive cells and an inducible Cre-LoxP recombination system to address the role of Fgf8 in Tbx1 positive...

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Identifiers

PMID: 16696966
DOI: 10.1016/j.ydbio.2006.03.044
PMCID: PMC1850621

Genes

TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.PMID 16696966Read ↗

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.Semantic proximity Read ↗

Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling.Semantic proximity Read ↗

Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways.Semantic proximity Read ↗

Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouseSemantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesisSemantic proximity Read ↗

<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4 <sup>th</sup> pharyngeal arch artery morphogenesisSemantic proximity Read ↗

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis.Semantic proximity Read ↗

Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.Semantic proximity Read ↗

Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.Semantic proximity Read ↗

Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8.Semantic proximity Read ↗

Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.Semantic proximity Read ↗

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