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Article

ABCC11/MRP8 confers pemetrexed resistance in lung cancer.

Cancer science - 1 Nov 2010

Uemura Takehiro, Oguri Tetsuya, Ozasa Hiroaki, Takakuwa Osamu, Miyazaki Mikinori, Maeno Ken, Sato Shigeki, Ueda Ryuzo

Abstract excerpt

We have previously shown that overexpression of thymidylate synthetase (TS) resulted in pemetrexed (MTA) resistance. To investigate another mechanism of MTA resistance, we investigated the expression of ATP-binding cassette (ABC)-transporters in MTA-resistant lung cancer cell lines and found that...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

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Source

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Identifiers

PMID: 20718756
DOI: 10.1111/j.1349-7006.2010.01690.x
PMCID: PMC11158034

Genes

ABCC11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20718756-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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