Article
Mechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase.
The Journal of biological chemistry - 6 Mar 2009
Sherrer Shanen M, Brown Jessica A, Pack Lindsey R, Jasti Vijay P, Fowler Jason D, Basu Ashis K, Suo Zucai
Abstract excerpt
1-nitropyrene, the most abundant nitro polycyclic aromatic hydrocarbon in diesel emissions, has been found to react with DNA to form predominantly N-(deoxyguanosin-8-yl)-1-aminopyrene (dGAP). This bulky adduct has been shown to induce genetic mutations, which may implicate Y-family DNA polymerases in its bypass in vivo. To establish a kinetic mechanism for the bypass of such a prototype single-base lesion, we...
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