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Article

Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site.

The Journal of biological chemistry - 31 May 2002

Kokoska Robert J, Bebenek Katarzyna, Boudsocq Francois, Woodgate Roger, Kunkel Thomas A

Abstract excerpt

Sulfolobus solfataricus DNA polymerase IV (Dpo4) is a member of the Y family of DNA polymerases whose crystal structure has recently been solved. As a model for other evolutionarily conserved Y family members that perform translesion DNA synthesis and have low fidelity, we describe here the base substitution and frameshift fidelity of DNA synthesis by Dpo4. Dpo4 generates all 12 base-base mismatches at high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11919199
DOI: 10.1074/jbc.M202021200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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